We search for significance… in all the wrong places.
Significance is a sign that a given manifestation (aspect) of reality equals: ______________ (your mind fills in the blank).
Indeed, significance is an equation between something outside of you and something inside you, a moment in which a particular manifestation of reality translates into a feeling of significance and a thought of significance.
Case in point: say you have a crush on a co-worker. As you walk past her desk, she looks up. This moment, this manifestation of outside reality translates into a feeling of significance (your heart skips its regular beat as the sympathetic nervous system revs up in response to the possibility of sympathy) and a thought of jubilation (perhaps: “she/he likes me!”). But, of course, so far it’s just a hypothesis – but its very fact is enough to make your heart skip a beat.