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Stress, Brain Changes, and Depression

Stress, Brain Changes, & DepressionYou probably already know at an intuitive level that after feeling anxious and stressed for awhile, your mood tends to dip a bit. Maybe you’re just mildly dejected, or perhaps you develop a full-fledged depression. Unfortunately, it can get worse, assuming that what holds true for mice holds true for humans — if you’ve been traumatized, your brain can actually go through significant hormonal changes that can plummet you into a chemical depression for months — leaving you to hang on to faith that you’ve eventually feel better, at a time when faith is probably the last thing you’re likely to experience.

Researchers at the University of Washington have recently discovered that a neuropeptide called corticotropin-releasing factor (CRF), which under normal conditions helps the brain to release dopamine, a hormone associated with pleasurable sensations, loses this ability under stressful conditions, for over three months. That’s a long time. 

In the study, mice were put in one of two connected cages. In the first cage, an area of their brain called the nucleus accumbens was infused with CRF. The mice were then moved into the second cage, and their nucleus accumbens was infused with a placebo (inactive) substance. The mice were then left to pick their preferred cage, the hypothesis being that the mice would choose the cage where they experienced a gratifying dopamine surge (i.e., the cage where they received CRF). This was indeed the case.

Next, the mice were subjected to a stressful situation, in this case, being forced to swim in water many times over two days. The researchers found that after this stressor, the ability of CRF to boost the release of dopamine in the brains of the mice was obliterated. Moreover, the mice actually wanted to spend less time in the cage where they received CRF, indicating that CRF was producing a distasteful (not just a neutral) effect  — and this persisted for over 90 days.

So, if you’ve experienced a traumatic event that caused you significant stress, be aware that your body is going through some major biochemical changes and may be sending you confusing signals. As a result, you may sink into depression — and possibly for an extended period of time. If you experience symptoms such as decreased enjoyment of activities that you usually enjoy, less interest in socializing, and alterations in sleep and eating patterns, try not to berate yourself.

Instead, be patient, understand that your body needs time to heal, and try to reach out for support from family, friends, and mental health professionals, if needed.

Also, do your best to practice good self-care (see Things Your Brain Needs to Function Correctly and 14 Ways to Manage Anxiety).

It’s hard to take action when it feels as if nothing will help or ever change — but this is the depression talking, not the reality.

More information: Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive, Nature (2012) doi:10.1038/nature11436

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Stress, Brain Changes, and Depression

Rachel Fintzy Woods, MA, LMFT

Rachel Fintzy Woods, M.A., LMFT is a licensed psychotherapist in Santa Monica, California. Rachel counsels in the areas of relationships, the mind/body connection, emotion regulation, stress management, mindfulness, emotional eating, compulsive behaviors, self-compassion, and effective self-care. Trained in both clinical psychology and theater arts, Rachel works with people to uncover and develop their unique creative gifts and find personal fulfillment. For 17 years, Rachel has also been conducting clinical research studies at University of California, Los Angeles (UCLA) in the areas of mind/body medicine and the interaction of psychological well-being, social support, traumatic injury, and substance use. You can read more about Rachel at her website:

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APA Reference
Fintzy Woods, R. (2017). Stress, Brain Changes, and Depression. Psych Central. Retrieved on August 15, 2020, from


Last updated: 17 Jul 2017
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