Treatment of Nightmares with Prazosin: A Systematic Review

– A researcher from the Mayo Clinic discusses his newly published review of literature on the use of prazosin for PTSD-related nightmares. There’s compelling evidence for its effectiveness. In 12 studies, more than half the patients who tried it got better. The main limitation was a small sample size (249 patients in total).

Nightmares are a difficult symptom of PTSD and this is hopeful news that people can discuss with their doctors.

For full details of the review and how prazosin affects the adrenal system, read the accompanying journal article: “Treatment of Nightmares with Prazosin: A Systematic Review,” Kung et al., Mayo Clinic Proceedings, September 2012.