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Bipolar Disorder Medication Spotlight: Lithium Orotate

A number of people have written about their experiences with lithium orotate as an alternative to pharmaceutical lithium (lithium carbonate or lithium citrate). I wanted to know more about it, so I reviewed the research. The bottom line is that we know very little about lithium orotate – the data is scant and old and tells us very little about the safety or effectiveness of lithium orotate as a substitute for lithium carbonate, the standard formulation.

33 Comments to
Bipolar Disorder Medication Spotlight: Lithium Orotate

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  1. I just want to comment that it is the lithium, not the compounds it is attached to, that is important in the treatment of bipolar. Just because sometime is heavily researched, such as pharmaceutical lithium, does not mean it is good. If you need more proof just Google Vioxx.

    Second, all supplements are goverend by the FDA. That is an brash statement to throw out there. The truth is supplement companies are goverend by the FDA (DSHEA Act), but that does not mean all companies are equal. Furthormore, very few physicians are actually trained on supplements let alone the differences on companies. Go to Not all of these physcians use supplements but they will be able to refer you to someone who does.

    • To the person who said its lithium not the the compound its attached too. While lithium is the element that causes stabilization the compound its attached to might effect bioavailability, half-life, etc. For example magnesium oxide is very poorly absorbed by the body whereas magnesium citrate and certain others are absorbed rather well. You would not get the same amount of magneium with both compounds so the type of lithium compound you take could very well influence how much is utilized.

  2. My Girlfriend was recently diagnosed with Bipolar Disorder Type 2, and was put on Lithium Orotate, which showed immediate positive effects.

    I would like to point out from a chemistry perspective, that Lithium Carbonate is a synthetic chemical which is why it can be patented and sold to the public, and Lithium Orotate is naturally occurring and from what I have read, actually causes no toxicity, unlike Lithium Carbonate.

    We will continue to use the naturally occurring, cheap alternative to what big pharma is trying to sell us. After all, if I was them I would poison every american too so I could keep them sick ad continue to make money off of them. Then I would pay med schools to train doctors to treat symptoms and not solve the cause. Then I would be rich!!!

  3. I’ve tryed many mediactions because of my moodproblem.

    Noy I’ve a actinic dermatitis because of SSRIs and a blepharospasm because of antypsychotics. Since the blepharospasm I also have problems feeling my right side of the face.
    If I would have known it, I’d rather just stayed depressed. This has nearly destroyed my live. I was much worser than bevore. I didn’t know that this can happen.

    And those are just the most serious side effects who stayed.

    My new psychiatrist doesn’t want to give me any medication, because of my experiences in the past because she doesn’t wants to be responsible.
    I can’t blame her, it’s just the way it is.

    I started to try OTC more or less natural medicine.
    And ended up with:
    * Rhodiola Rosea
    * Cod Liver Oil
    * Melatonin
    * Lithium Orotate

    I take those since nearly two months and lithium orotate since one week in addition and the first time since years I’m nearly free of depressions.
    Allready Melatonin (being able to sleep again), Rhodiola Rosea and Cod Liver Oil has helped me a lot. I also took Tyrosine for a while. It also helped, but I wasn’t totally hapy with my mood. So now I look that my food has a lot of Tyrsoine and Lysine, but don’t take it as a medication.
    Even my skin got a lot better because of the Cod Liver Oil (it contains a lot of vitamin D).

  4. Could you please correct the info on your site about lithium orotate and kidney Danger? Info below. Thank you.

    There is no research or study of any kind showing that lithium orotate is dangerous to use. The much-quoted conclusion of the 1978 Smith and Schou study that can be found at PubMed is INCORRECT for the reasons explained below.

    The study compared the effects on kidney function of lithium carbonate and lithium orotate.

    Results indicated lowered kidney function with lithium orotate, and concluded that it seemed inadvisable to use lithium orotate in the treatment of patients.


    An effective dose of lithium orotate typically contains 15 mg of elemental lithium compared to the 126 mg of elemental lithium from lithium carbonate.

    Based on the information from the Smith and Schou study stating that equal amounts of lithium carbonate and lithium orotate were used,

    Ironically, the 1978 Smith and Schou study which concluded that lithium orotate was inadvisable for treatment of patients, was done as a direct follow-up study to one performed earlier in 1978 by Kling, Manowitz and Pollack. That study suggested that lithium orotate could be used in lower amounts than required of lithium carbonate to achieve therapeutic results.

  5. Hej
    My son have bipolar, and we have been seaching after infomation about lithium orotate, here in Denmark. Unfortunately there is nothing , we can not buy it here..
    So all the informations I have is from American internet and you tube.

    We were recently at his psychiatrist, he had never heard of it. and would not take responsibility for it.

    I bought something from abroad, but now I do not dare use it when I can not cooperate with the doctors.

    I wish there was more cooperation, but it’s probably dosen’t happend. It seams to be a good product for bipolar. when you say it is used in Europe, I can not quite understand it. certainly not in Denmark

  6. I have OCD and bipolar tendencies and have been taking lithium orotate for a few months now. Personally, i’ve noticed drastic effects, as far as it reducing the extremes between moods. I’ve cycled on/off of lithium a few times, just testing to see if it’s really all that effective. What i’ve found is that when I stop taking it a few days, I’ll either gradually go into a restless manic stage or a depressive hopeless stage. In mania, I have to consistently be productive and my thinking moves so fast, concentration almost becomes impossible. I can deal with the mania, it’s the depressive stage that worries me most. It’s almost unbearable, in a sense that all I want is to die… There’s essentially no difference in diet, sleeping, or anything I can think of that’d cause this drastic of a difference, other than the lithium orotate… Personally, i’ve noticed drastic effects from taking it, obviously everyone is different…

  7. Thanks for publishing the little bit of research that exists on lithium orotate.

    I’m not a chemist, but find one and s/he’ll say that there is no way on earth that the orotate molecule could hang onto the tiny lithium ion once they get out of the intestine. The same applies to cousins on the periodic table, sodium and potassium.

    So the claim that lithium orotate provides selective delivery to brain cells is just incredible. You can chelate some metals in the body, but not lithium.

    Probably it has been the quick perception of this inherent impossibility that has caused a lack of research. Biochemists and pharmacologists don’t like wasting time on the equivalent of trisecting the angle.

    • I’m also sceptical about that theory. But never the less Lithium Orotate also works in small amounts. I tested some substances and Lithium Orotate was still one of the best helping me with my mood swings.

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