Archives for Genetics

Stem Cell Research Sheds Light on Genetic Factor in Bipolar Disorder

A study published last month in a journal called Translational Psychiatry entitled "Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients" reported interesting findings about the development of brain cells in people with bipolar disorder compared to controls — people without bipolar disorder. The study was unique in two important ways:

The study was based on the increasingly accepted concept that even subtle changes in early embryonic brain development can cause symptoms of...
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Antipsychotic

Do Antipsychotics Work by Affecting Gene Function in Bipolar?

Researchers at the University of Michigan have discovered that antipsychotics may work, at least in part, by restoring normal gene function in people with bipolar disorder. (Chen, H., Wang, N., Zhao, X., Ross, C. A., O’Shea, K. S. and McInnis, M. G. (2013), "Gene expression alterations in bipolar disorder postmortem brains." Bipolar Disorders, 15: 177–187. doi: )

The research team did post-mortem (after death) examinations on the brains of three groups of people:

People with bipolar disorder...
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Genetic Region PBRM1 Associated with Bipolar Disorder

October 15, 2012, researchers at Kings College in London published a study in the journal Biological Psychiatry, entitled "Replication study and meta-analysis in European samples supports association of the locus with bipolar disorder" Biological Psychiatry. 2012 Oct 15;72(8):645-50. Vassos E, et al.) This study replicates earlier findings that connect changes at a particular gene region on chromosome to bipolar disorder.
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Bipolar Research

NCAN Gene Linked to Mania

In the September issue of the American Journal of Psychiatry, researchers report a series of studies that suggest a strong association between one particular genetic variation and manic symptoms. (Studies in humans and mice implicate neurocan in the etiology of mania. Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram O, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher...
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Bipolar Medication

Using Genetic Profiles to Predict Medication Response in Bipolar Disorder

This month's edition of Discovery's Edge, Mayo Clinic's Online Research Magazine, features an article entitled "The Genomics of Bipolar Disorder." The article looks at biobanking – a practice in which research centers store a lot of information on thousands of people with certain disorders, in this case bipolar. Mayo Clinic, in conjunction with several other research centers, is collecting blood samples and clinical information from 2,000 patients. This...
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Genetics

Where’s the Bipolar Gene?

Given all the activity and advances in genetic research, you might expect researchers to have mapped the entire human genome by now and identified the gene or genes responsible for bipolar disorder and other diseases that appear to have a genetic component. Obviously, that hasn't happened. The best that researchers seem to have come up with are associations of certain gene variations with bipolar – hardly the smoking gun we would hope for.

Even...
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Bipolar Research

Scientists Identify Possible Genetic Risk for Suicide Attempts

In a study published in the journal Molecular Psychiatry entitled "A genome-wide association study of attempted suicide," a group of Johns Hopkins researchers (Willour, et al.) report the discovery of a "a small region on chromosome 2 that is associated with increased risk for attempted suicide."
Willour and her colleagues studied DNA samples from nearly 2,700 adults with bipolar disorder, 1,201 of them with a history of suicide attempts...
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Bipolar Research

New Genetic Link to Bipolar Disorder

Psych Central's Senior News Editor Rick Nauert recently posted a piece entitled "Genetic Variant Heightens Risk for Bipolar Disorder." In it, he calls attention to a recent study published in the American Journal of Human Genetics that's "based on a relatively new technique for the study of the genetics of bipolar disorder" termed genome-wide association studies (GWAS).

We invite you to check out the post, especially if you're interested in keeping...
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