Archives for Side Effects

Bipolar Medication

Body Shaming Weighing You Down?

People with bipolar disorder often struggle with weight gain, because it's a side effect of so many medications used to treat depression and mania. Compounding the issue is the fact that the more you worry about weight and try to "shed the pounds" the harder it may be to lose weight. Meanwhile, all you accomplish is feeling bad about your body.

I recommend a different approach, one that focuses on health and...
Continue Reading

Bipolar Medication

Taking an Anti-Inflammatory (NSAID)? Check Your Lithium Levels

My wife is seeing a psychiatrist who prescribed lithium for her bipolar disorder. Recently, she visited another doctor, who prescribed Mobic (meloxicam), a nonsteroidal anti-inflammatory drug (NSAID), for pain and swelling in her knee. A couple weeks later, we spent the afternoon in the emergency room, where my wife was treated for lithium toxicity and had her lithium blood level checked.
Continue Reading

Antipsychotic

Do Antipsychotics Work by Affecting Gene Function in Bipolar?

Researchers at the University of Michigan have discovered that antipsychotics may work, at least in part, by restoring normal gene function in people with bipolar disorder. (Chen, H., Wang, N., Zhao, X., Ross, C. A., O’Shea, K. S. and McInnis, M. G. (2013), "Gene expression alterations in bipolar disorder postmortem brains." Bipolar Disorders, 15: 177–187. doi: )

The research team did post-mortem (after death) examinations on the brains of three groups of people:

People with bipolar disorder...
Continue Reading

Bipolar Medication

Ebselen May Work Like Lithium with Fewer Serious Side Effects

According to a recent study published in the journal Nature Communications entitled "A safe lithium mimetic for bipolar disorder," British researchers are exploring a medication called ebselen as a possible treatment for bipolar disorder in humans. Originally developed to treat stroke, ebselen may be as effective as lithium in treating bipolar mania but carry fewer and less serious side effects than lithium.

As the article points out,
Lithium is the most effective mood stabilizer...
Continue Reading

Evidence for Abilify (Aripiprazole) in Maintenance of Bipolar Disorder Questioned

Abilify (aripiprazole) is an atypical antipsychotic medication commonly used to treat schizophrenia and acute mania. In 2005, the Food and Drug Administration (FDA) approved its use in the maintenance treatment of bipolar disorder – to prevent the recurrence of mood episodes. Unfortunately, evidence proving the effectiveness of Abilify as a maintenance medication for bipolar disorder is scarce and questionable.

Exposing the Truth


An article published this week in the open access journal PLoS Medicine (Tsai et al) looks critically at the scientific evidence that...
Continue Reading