Comments on
7 Deadliest Drug Combinations


Despite warning labels on prescription pill bottles and frequent news reports of celebrity overdoses, people are not taking the risks of fatal drug combinations seriously. Prescription drugs and alcohol are legal,

19 thoughts on “7 Deadliest Drug Combinations

  • April 18, 2012 at 8:25 pm

    hi , I am studying herbal medicine,1st year and in this article i see it refed to that doctor and pharmacist know best. I work in a busy meical pharmacy and the most horrific phraze i hear from our head pharmacist is that is ok, as if he knows best about the herbs as well, do they know all the interactions, and what is in the plants, this is a herblist and natrupaths jobs to know a pharmacist know the chemicals not the whole plants use. consult a registered herblist when dealing with herbs, that is there specility

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  • April 20, 2012 at 10:15 am

    Just so you know not all liver damage is done by drinking alcohol. I have NASH and am on the transplant list at UCSF. This was not my choice to have a bad liver but on facebook it sounds like you put the two together.

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  • February 3, 2013 at 10:39 am

    Hello, I am looking for info on interactions with effexor xr and clonzepam (klonopin) my chiro gave me a supplement of magnesium lactate bio standard i think it’s called that is a whole food supplement that is not supposed to hurt your stomach i have severe menstrual cramps and also tmj. so i am a little nervous about taking this and i can’t seem to find any info on interactions… any info would be appreciated. also can’t seem to take the edge of my anxiety so hoping for some calm.

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    • February 3, 2013 at 10:54 am

      sorry i meant standard process

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    • February 2, 2018 at 12:41 pm

      I also take Effexor I was on extended release just recently had it changed I also take Klonopin .5 twice a day as needed 4 I have terrible anxiety. I’ve never had depression or anxiety or any other symptoms that I have until I had my thyroid removed I haven’t noticed anything alarming with mixing the two

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  • April 13, 2013 at 5:19 pm

    ..it’s been a year in May, since I woke up in the ICU of a local hospital, confused, in excruciating pain… bloody hoses coming out of my mouth, full of blood, my face, jaws, chin, nose, both sinus cavities, top and bottom right eye socket and cheekbone smashed, broken, fractured from left to right, top to bottom.
    My surgeons said ” you got somebody mad at you”.
    I had swollen, black and blue backs of my forearms, especially the right one, a hematoma on my right chest but no other marks anywhere- not on my hips, ellbows, knees, no dirt on my clothes. Absolutely nothing on my motorcycle – not a dent,broken light, mirror, lever. And it was found half on the asphalt and half on the median curbstone.
    Months later, when my spinning head had somewhat come to a more ‘normal’ speed, I found out by accident ( obtained hospital records to see the xtend of my facial fractures, jaws still wired shut, metal plates all over, even my eye sockets)and to my indescribable shock that someone had put benzodiazepenes, opiates and a huge amount of ethanol into my body – presumably via drink. No, I don’t recall tasting anything ‘weird” or smelling anything unusual. Believe it, I have been asked that, with an undertone of disbelief , as if I were making it up, as if I had consciously put drugs into my body. In my research I have found that this mix is highly unusual and ,potentially, quite lethal. It is NOT a ” roofie” or “date rape drug” mix. It had more of a sinister intent. ( not saying that ANY excuse or justification can be made for ANYone manipulating drugs of ANY sort into another being’s body.) No progress has been made to find and hold responsible those who did this to me. People have a tendency to ‘shrug it off” if they’re not the ones affected. So, don’t go looking for help- you won’t get it. Pay attention. Trust your instincts. If your gut tells you someone is not a ‘nice” specimen- trust your gut. Stay away. Buy a new drink if you leave yours unattended, even if just for a second. If, suddenly, someone attacks you verbally, causing a big to-do that makes no sense, is confusing, upsetting to you – walk away, leave your drink behind. It’s called a diversion to get everyone’s attention away from what’s happening – someone squirting the potentially lethal mix into your drink. They come prepared. They do their thing. And watch. They had to follow me to a second location – my surgeons say that my adrenaline level was so high from the upset, that I was able to move away, ride on my motorcycle, from the first location, which may very well have saved my life . They followed and waited for me , the opportune moment, there. That moment came when I left the second location to ride home.
    I had no memory of anything, at first. Except those two men screaming bizarr, confusing, nonsensical things, threatening, being in my face. My head was swirling.
    According to witnesses I rode my bike from point A to point B as always, nothing unusual was apparent. I had, however, given my camera bag to a trusted friend and never came back to get it , and my head fell back, my eyes rolled – but nobody did anything. I am told they just thought I “may have had a beer too many”. I don’t ‘drink” – never do drugs, don’t do shots. I may have a beer or two. That day I had 6 beers over a period of 12 hours. . So much for having friend around to feel safe. You can’t rely on that, regardless of how wonderful your friends seem to be. The situation and behavior that day were so unusual that they did – nothing. My best friend, one of my last memories, infuriated me by a) standinig by and pretending not to notice and then, after they had finally left, insisting – in a breathtakingly patronizing way some speak to geriatric Alzheimer patients- that those 2 men probably didn’t have any breakfast, trying to ridicule the event, to the point of me- also very unusual- yelling at him to “shut up and zip it” . He then left in a huff. After I was released from the hospital, I was amazed by some people’s reactions. A flood of wonderful, warm, heartfeeling, fuzzy people who embraced and comforted me on one side – and those who acted as if they had been there- but weren’t. Tried to spread the rumor that I had been given the drugs at a prior event 12 hours earlier ( I write and take pictures for a magazine), I had been drugged and beaten by a motorcycle club ( utter nonsense), I had been ” just drunk as a skunk”, I had brought it on myself, justifiedly so, in other words. If it’s your own fault, in other words, they won’t have to think about it, you deserved it and it won’t happen to them. Ever. One woman gave me the good advice to “take a good hard look at yourself” . Another cut me off after asking me how I was, saying she “can see you’re doing WELL.” ( at a time I was going crazy with pain, fell when looking up and had my first strong bouts with PTSD) . When I found out about the drugs and got my head together about that, I wanted to warn people. The woman who owns the venue were the drugs were given to me, said ( quite upset): I GUARANTEE you, nothing like this would EVER happen at MY establishment. You must have been given those drugs somewhere else. I’m sure she meant well. I was told ‘epople’ said I were a nutcase ( ‘crackpot’ was the quote). That can happen to you. More often than not, people will choose to ignore signs of trouble, stick their heads in the sand. for the sake of comfort. That can kill you. So: watch your surroundings. When in doubt, buy a new drink – it’s still cheaper than losing time off work, or your job, your health or your life. Don’t trust that others will help you. Even the best of friends will be inactive if that means their comfort will remain undisturbed. Be your own best friend. Sad but true. Be pro-active and avoid bad situations by not getting into them. Why am I writing this? I carry the desperate hope that someone will come forward with info about the event, the kind of person who will do such a thing, the psyche of such a perpetrator (profile) – ANY kind of general or focused input about that drug mix, about that kind of person, that kind of profile, psyche that will help me pinpoint, solve this and finally get over my emotional trauma. I am hoping it won’t happen to anyone else. I know that’s not realistic. Nothing ventures, nothing gained – if this keeps just one soul from experiencing the same thing I have been and am experiencing, it’s worth putting out there.

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    • October 20, 2014 at 5:06 pm

      I’m calling full of crap. Your not a “drinker” but you had 6 beers? Good story to try and bypass getting a DUI.

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      • January 8, 2015 at 8:12 am

        Really! Do you seriously believe she would have had all those other drugs noted in her tox screen if she had only beer! You need to do your research and maybe find some compassion while your at it.

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    • January 8, 2015 at 8:11 am

      I believe you. It is extremely easy for someone to drug your drink. You are not responsible no matter what the naysayers say. Whether you had 1 beer or 6 – the drugs found in your body from the tox screen would not show up. You take good care of yourself and be kind to yourself too. You went through and awful ordeal and don’t need anyone to judge you.
      My prayers are with you.

      Reply
  • July 20, 2014 at 7:18 pm

    I came across this site while searching for answers of mixing drugs & alcohol. I have been off and on Zoloft for 10 months. Started out 50mg now on 200mg. As I began feeling better on the Zoloft I found myself being more active and getting out. Soon I was back in the mix of the party scene. Where I found old friends and old habits. The heavy drinking and meth use (smoking) was only a weekend thing. But now after a 4 year relationship ended on May 23, it has gotten out of control. My Zoloft is up to 200mg daily. My binge drinking is every 2-3 days. And although I have isolated myself from the outside world, I still find myself using meth.
    Now my question is, is all this deadly or only mixing 2 of the 3? What signs should I look out for that can lead to health problems? Also, I’m aware that meth is not the way to go. However, it gets me up and out of the house.

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    • July 28, 2014 at 8:05 pm

      If you are drinking heavily and using methamphetamine, please do not wait for health problems to appear. You are already putting yourself at risk for cardiovascular problems, depression, anxiety and other side effects. It’s vital to stop both behaviors. If you find yourself unable to stop, I encourage you to reach out for help through counseling, a rehabilitation program or a support group such as Alcoholics Anonymous. Also speak with your doctor about whether the dose of Zoloft you’re taking is appropriate. Each of these resources can help you learn ways to avoid turning to substances that seem to promise relief but only end up making problems worse.

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    • February 2, 2018 at 12:46 pm

      math is a terrible thing to put in your body so many household chemicals. Maybe try going to your doctor and telling them you have ADD or ADHD and are having trouble focusing and concentrating

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  • February 5, 2015 at 8:59 am

    I feel as though a big opportunity was missed to point out opiates and benzodiazepines. Now that’s one killer combo. Ask the Massachusetts department of public health

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    • July 28, 2017 at 9:25 pm

      Yeah if you are an idiot. Im from mass and been on benzos and painkillers for ever and never have od in my life let alone 5 to 10 other medications i take and drink and smoke tree. Everyone has the persona that youll die if u take benzos with painkillers and drink. Well you dont. You only do if you take to much or drink to much and combine them all at the same time. Im not a drug addict im severly mentally ill and i aint dead yet…

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    • July 28, 2017 at 9:30 pm

      No it isnt. Maybe if you are in highschool

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  • December 24, 2015 at 3:29 pm

    Im forced to take 5 psych meds,3 diabetic meds & 4 pain killers ( for bad arthritis in knee , back and shoulder). I use the same pharmacy and they’ve caught several drug interactions. I understood your srticle as trying to take as little meds as possible. I dont have a choice. If i dont take the psych meds i become either depressed or manic ending on the psch ward. If i dont take diabetes meds or i die. Ive got no choice here. I wish i didnt have this problem. Infact i got diabetes from taking high doses of seroquel (which I’m still on because it’s the main mood stalizer that works) 800mg is so much but I’ve got a very high tolerance. It doesnt even help me sleep. I wish I didn’t have to take any pills but this is the life God has dealt me:(. Maybe one day they’ll find a cure for both bipolar and diabetes and my life will finally be normal…

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    • May 27, 2016 at 1:48 am

      Hi, we are in the same arthritis boat. i still can’t afford to consult with Dr. Daniel Amen of the Amenclinics.com.I have been reading up on him since1998. I found his aporoach to psychiatry very impressive. He uses brain imaging to better treat his patients. I have yet to hear of any other psychiatrists (outside of his clinics) who use his approach. I will have to afford his services before this yr is over. My arthritis pain is worse now I may end up in a motorized scooter soon. My point is that pain is more of the brain responses to the bones/muscles/nerves, etc combined malfunctioning, that I am hopeful the concurrent psycho-effects may be alleviated better and safely with targeted treatment using the brain mapping techniques that Dr.Amen mentioned in his website. For your health & mine, pls get back to me after you see Dr. Amen. Thanks.

      Reply
  • August 29, 2016 at 4:13 pm

    A couple things about Coumadin/Warfarin:

    One, Potassium and Vitamin K are different, one is a mineral, the other a vitamin. Potassium does not affect Warfarin, Vitamin K will negate the effects of said drug.

    Two, Green vegetables will also thicken the blood, not thin it out. Kale is the toughest one, with spinach not far behind.

    I applaud your efforts in the attempt to educate. However, have a bit of due diligence before publishing this kind of information. Someone with a high Protime/INR from their Coumadin might eat a bushel of bananas and bleed out because they are filling up with potassium instead of vitamin K. They would either die from bleeding to death and with an arrhythmia to boot, just in case you are wondering, too much potassium can cause the same effects as too little.

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  • July 28, 2017 at 9:19 pm

    I take 2 mg of xanax, 2 mg of clonazepam, Tramadol, Resperidone, and 90 mg of Adderall everyday for a decade and im only 25 yrs old. and i drink, why am i not dead yet huh. Its all bullshit if you know what you are doing and know when to take the medicine the combinations doesnt mean anything unless ur a dumb kid or an idiot. I should be dead being prescribed duplications of benzos, pain killers for a severe spinal cord and neck injury, high doses of adderall for adhd, resperdione for bipolar 1 disorder. Im still standing and have never od in my life. Im i some sort of sick pill popping animal?

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