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After five years together, award-winning actor/comedian Jim Carrey and actress-turned-activist Jenny McCarthy have called it quits, and some sources have reported the cause of the break up might be the stress of dealing with Carrey’s depression, McCarthy’s son’s autism, or both.

I don’t think there’s been any confirmation from Carrey or McCarthy (PopStar quotes a vague statement from Carrey’s rep, and both have tweeted they’re grateful for the time together, with Carrey wishing McCarthy “the very best” and McCarthy claiming Carrey will always be “a leading man in [her] heart”), but speculating that the stress of either — or both — of those situations could be reasons for the split wouldn’t be too far-fetched.

ABC quotes Lori Warner, director of Michigan’s Beaumont Hospital’s HOPE Center, as stating “Popular estimates of the divorce rate of parents of children with autism are 80 percent and above,” and anyone who’s ever dealt with depression or known someone who’s had depression knows what kind of havoc it can wreak on any kind of relationship if gone unchecked.

Whatever the reason(s), for now the break-up seems to have been a mutual decision and, well, fairly pleasant as far as break-ups go.

What kinds of stresses have mental health problems caused your relationships? Have you ever experienced a break-up due to depression, bipolar disorder, anxiety, or any other mental health issue? Or, on the flip side, have you ever experienced a relationship that helped you better care for your mental health?