Bipolar Research Articles

Stem Cell Research Sheds Light on Genetic Factor in Bipolar Disorder

Tuesday, April 8th, 2014

A study published last month in a journal called Translational Psychiatry entitled “Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients” reported interesting findings about the development of brain cells in people with bipolar disorder compared to controls — people without bipolar disorder. The study was unique in two important ways:

  • The study was based on the increasingly accepted concept that even subtle changes in early embryonic brain development can cause symptoms of mental illness that appear later in life.
  • The researchers took advantage of evolving technology that creates stem cells — the origin cells in embryos that evolve into all the different cells types in the body — from adults rather than taking them from embryos. This allows researchers to have access to many more stem cells and also offers the opportunity to compare the stem cells from adults with certain diseases to those without and to see differences in the way they develop.


Do Antipsychotics Work by Affecting Gene Function in Bipolar?

Friday, April 19th, 2013

genecrpdResearchers at the University of Michigan have discovered that antipsychotics may work, at least in part, by restoring normal gene function in people with bipolar disorder. (Chen, H., Wang, N., Zhao, X., Ross, C. A., O’Shea, K. S. and McInnis, M. G. (2013), “Gene expression alterations in bipolar disorder postmortem brains.” Bipolar Disorders, 15: 177–187. doi: 10.1111/bdi.12039)

The research team did post-mortem (after death) examinations on the brains of three groups of people:

  • People with bipolar disorder who never took antipsychotics
  • People with bipolar disorder who had taken antipsychotics
  • People without bipolar disorder (the control group)

Mood Disorder Clinics Reduce Hospital Readmission Rates

Tuesday, February 12th, 2013

depressedcrpdResearchers in Denmark have discovered that treatment in specialized mood disorder clinics following a hospitalization significantly reduce hospital readmission rates.

In their study, published in the British Journal of Psychiatry and titled “Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial,” Lars Vedel Kessing et al. followed 158 patients who were discharged from their first, second, or third hospital admission with a single manic episode or bipolar disorder.


Ebselen May Work Like Lithium with Fewer Serious Side Effects

Tuesday, January 8th, 2013

bipolar medicationAccording to a recent study published in the journal Nature Communications entitled “A safe lithium mimetic for bipolar disorder,” British researchers are exploring a medication called ebselen as a possible treatment for bipolar disorder in humans. Originally developed to treat stroke, ebselen may be as effective as lithium in treating bipolar mania but carry fewer and less serious side effects than lithium.

As the article points out,

Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects.


Genetic Region PBRM1 Associated with Bipolar Disorder

Wednesday, November 7th, 2012

October 15, 2012, researchers at Kings College in London published a study in the journal Biological Psychiatry, entitled “Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorderBiological Psychiatry. 2012 Oct 15;72(8):645-50. Vassos E, et al.) This study replicates earlier findings that connect changes at a particular gene region on chromosome 3p21.1 to bipolar disorder.


Mental Illness Stigma or Discrimination?

Friday, September 21st, 2012

mental illness and familyThe Fall edition of the NAMI Advocate (2012) contains an interesting article by NAMI Communications Coordinator Brendan McLean entitled “The Hope for Mental Illness Research: Dr. Tom Insel Shares the Latest Data at NAMI Convention.” But it wasn’t the discussion about research that piqued my interest. Instead, it was what Dr. Insel said about stigma and the importance of engaging the family in the recovery process.

Stigma Versus Discrimination


NCAN Gene Linked to Mania

Thursday, September 20th, 2012

NCAN geneIn the September issue of the American Journal of Psychiatry, researchers report a series of studies that suggest a strong association between one particular genetic variation and manic symptoms. (Studies in humans and mice implicate neurocan in the etiology of mania. Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram O, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. Am J Psychiatry, 2012 Sep 1;169(9):982-90.)


Brain Quote

Wednesday, September 5th, 2012

If the human brain were so simple we could understand it, we would be so simple we couldn’t.

–Emerson M. Pugh as quoted by George E. Pugh, The Biological Origin of Human Values, 1977


Regulating Your Circadian Rhythm with Lithium

Wednesday, March 14th, 2012

In a study just published on PLoS One entitled “Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork,” researchers at the University of Manchester (Jian Li, Wei-Qun Lu, Stephen Beesley, Andrew S. I. Loudon, and Qing-Jun Meng) have discovered that lithium works as a pacemaker for the circadian clock, which may help to explain lithium’s mechanism of action – how it works.


Bipolar Disorder and Aging

Thursday, October 20th, 2011

I recently got a call from an aging family member who has suffered with bipolar disorder, untreated for most of his life. He explained to me about the police cars that had “surrounded” his home and were “monitoring” him, but really were trying to harm him because they were involved in a “conspiracy with the gangsters who live down the street.”

I sighed. This was just another in a long line of these kinds of episodes, and I was pretty sure it would resolve on its own with my relative hunkering down in his house for a while until he was sure the police had gone away.

But then I decided to go see him as soon as I could, because he just turned 80 and I began to wonder if I should be worried that in addition to his bipolar disorder he might not be showing some signs of dementia. I wasn’t sure about the overlap between bipolar and dementia. We know from studies that people with bipolar disorder often have cognitive problems – memory, executive function, and other thinking problems. But does this put them at higher risk for memory problems in old age?


Bipolar Beat


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Candida Fink, M.D. and Joe Kraynak are authors of
Bipolar Disorder for Dummies.


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