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SSRI Articles

NSAIDs May Reduce Effectiveness of SSRIs

Tuesday, July 26th, 2011

transparent man's head high lighting the brainIf you’re taking a selective serotonin reuptake inhibitor (an SSRI antidepressant) that doesn’t seem to be working very well and you take nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, to relieve pain, that NSAID may be the reason why your SSRI isn’t working.

Recently Paul Greengard PhD published a report in an online journal that strongly suggests that treatment with NSAIDs may reduce the antidepressant activity of SSRIs. Their research is based on the theory that depression is at least partially related to the body’s inflammatory responses. This is called the cytokine hypothesis and is based on observations that some chemicals released as part of inflammation – cytokines – are involved in regulating neurotransmitters such as serotonin.


SSRI Antidepressants Linked to Decreases in Bone Density

Tuesday, July 13th, 2010

Over the last several years, a number of studies have found a relationship between decreased bone mineral density – bone strength – and long-term use of SSRI antidepressants. The theory behind this association is that serotonin is part of the system that regulates signaling in bone cells and that medicines that affect the serotonin system could change bone metabolism.

At the American Psychiatric Association meeting in May of this year, researchers from Canada (Bolton, et al. 2010) presented a large, well done study that provides even more evidence that bone density can be reduced in people taking SSRI’s for long periods of time. Following are additional details from the study:


Bipolar Disorder Medication Spotlight: Luvox (Fluvoxamine)

Friday, May 1st, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. We introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Luvox (fluvoxamine).


Bipolar Disorder Medication Spotlight: Lexapro (Escitalopram)

Friday, April 3rd, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. We introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Lexapro (escitalopram).


Bipolar Disorder Medication Spotlight: Celexa (Citalopram)

Friday, March 20th, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. We introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Celexa (citalopram).


Bipolar Disorder Medication Spotlight: Zoloft (Sertraline)

Friday, March 6th, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. We introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Zoloft (sertraline).


Bipolar Disorder Medication Spotlight: Paxil (Paroxetine Hydrochloride)

Friday, February 20th, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. Last week, we introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Paxil (paroxetine hydrochloride).


Bipolar Disorder Medication Spotlight: Prozac (Fluoxetine)

Friday, February 6th, 2009

With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. Over the past weeks, we covered several commonly used atypical antipsychotics, including Zyprexa (olanzapine), Risperdal (risperidone), and Seroquel (quetiapine). This week, we turn our attention to antidepressants, specifically the SSRI (Selective Serotonin Reuptake Inhibitor) variety. Medications in this class include:


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Candida Fink, M.D. and Joe Kraynak are authors of
Bipolar Disorder for Dummies.


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