Archives for Bipolar Medication


Reducing the Risk of Triggering Mania with the Use of Antidepressants in Bipolar Disorder

A recent article in the American Journal of Psychiatry sheds light on the vexing challenge of treating depression in individuals who have an underlying bipolar disorder: For many people with bipolar disorder, depression occurs more frequently and damages function more severely than mania, but treating bipolar depression with antidepressants carries the risk of triggering manic symptoms.
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Psychiatric Medications in Prison

About ten years ago, I was diagnosed as having bipolar disorder I. To qualify for a diagnosis of bipolar disorder I, you must have experienced at least one manic episode that was not triggered by medication or substance abuse. Most people with bipolar I experience depression, as well, but depression is not required for a diagnosis of bipolar I.

I have been in a Federal Detention Center (FDC) for the past five months. In accordance with my attorney's advice, I cannot discuss any details of the case. Recently, I have started corresponding with Joe Kraynak, coauthor of Bipolar Disorder For Dummies. He requested that I share my insights from inside the criminal justice system regarding the way medications are prescribed and administered.
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Bipolar Medication

Taking an Anti-Inflammatory (NSAID)? Check Your Lithium Levels

My wife is seeing a psychiatrist who prescribed lithium for her bipolar disorder. Recently, she visited another doctor, who prescribed Mobic (meloxicam), a nonsteroidal anti-inflammatory drug (NSAID), for pain and swelling in her knee. A couple weeks later, we spent the afternoon in the emergency room, where my wife was treated for lithium toxicity and had her lithium blood level checked.
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Do Antipsychotics Work by Affecting Gene Function in Bipolar?

Researchers at the University of Michigan have discovered that antipsychotics may work, at least in part, by restoring normal gene function in people with bipolar disorder. (Chen, H., Wang, N., Zhao, X., Ross, C. A., O’Shea, K. S. and McInnis, M. G. (2013), "Gene expression alterations in bipolar disorder postmortem brains." Bipolar Disorders, 15: 177–187. doi: 10.1111/bdi.12039)

The research team did post-mortem (after death) examinations on the brains of three groups of people:

People with bipolar disorder who never took antipsychotics
People with bipolar disorder who had taken antipsychotics
People without bipolar disorder (the control group)
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Bipolar Medication

Ebselen May Work Like Lithium with Fewer Serious Side Effects

According to a recent study published in the journal Nature Communications entitled "A safe lithium mimetic for bipolar disorder," British researchers are exploring a medication called ebselen as a possible treatment for bipolar disorder in humans. Originally developed to treat stroke, ebselen may be as effective as lithium in treating bipolar mania but carry fewer and less serious side effects than lithium.

As the article points out,
Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects.
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Lithium Overdose: What to Do and Not Do

A few weeks ago, my wife took too much lithium. She had had missed a few days of taking her lithium and decided to correct the problem by doubling her dose for a few days. As you might know or have surmised, that's a really bad idea. The difference between a therapeutic and toxic level of lithium is quite small.

Symptoms of lithium toxicity include the following:

Stomach pains
Hand tremors
Slurred speech

If you suspect that you may have taken too much lithium, stop taking the lithium and do one of the following:
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