Study Suggests Ziprasidone Less Effective in Treating Acute Mania in Patients with Obesity
At a recent meeting of the American Psychiatric Association, researchers presented a study suggesting that ziprasidone (Geodon) was less effective in treating acute mania in people with obesity or hyperglycemia (very high blood sugar level). The study was funded by Pfizer, which makes Geodon, and was done by looking at pooled data from previous studies performed by Pfizer looking at this medication’s effectiveness.
The lead author of the study, Roger S. McIntyre, Associate Professor of Psychiatry and Pharmacology at the University of Toronto, indicated that while the findings could be related to a need for higher doses in people with higher body mass indexes, it could also be that these differences in body mass and blood sugar could reduce the effectiveness of the drug at any dose. While this type of study is apparently uncommon in psychiatric research, it is actually quite important in helping us understand patterns of effectiveness in various medications used to treat bipolar disorder.


I can usually tell when a loved one is upset with me. They sulk around the house, bang stuff, slam doors and drawers, avoid eye contact, and stop talking to me. Maybe I know the signs because I engage in the same behaviors when I’m upset.
We rarely post on our original blog, Bipolar Blog, anymore; we maintain it primarily as a place where people can share their stories and insights of living with bipolar or with a bipolar loved one. I just posted a new story from Steve about his journey in rebuilding his life after receiving his diagnosis.
As a psychiatrist, every day I encounter families struggling with mental illness, especially in their children whose lives range from disrupted to shattered as a consequence of these challenges. In these daily battles I’m most frustrated and saddened by the jaw-dropping lack of compassion surrounding me and my patients regarding their family struggles and their child’s distress.
Last week, I attended a NAMI problem-solving workshop for people who have family members with serious mental illness, including bipolar disorder. The tone of the workshop was fairly low. Many attendees were feeling the strain of dealing with some very difficult situations.
If you think you qualify for Social Security Disability benefits, consider taking the following steps to pursue a claim:
The National Alliance on Mental Illness (NAMI) has a Stages of Emotional Responses chart that traces the emotional path people generally travel in coming to terms with their loved one’s mental illness. I’m pretty much at the final stage, Stage III: Moving into Advocacy, but I’m still sort of stuck at Stage II: Learning to Cope, which is characterized by Anger/Guilt/Resentment, Recognition and Grief.
