genetics, medication and bipolarThis month’s edition of Discovery’s Edge, Mayo Clinic’s Online Research Magazine, features an article entitled “The Genomics of Bipolar Disorder.” The article looks at biobanking – a practice in which research centers store a lot of information on thousands of people with certain disorders, in this case bipolar. Mayo Clinic, in conjunction with several other research centers, is collecting blood samples and clinical information from 2,000 patients. This information is stored anonymously, and researchers can use this high volume of data to look at specific questions about bipolar disorder.

The primary focus of this work is related to genomics – looking at genetic associations to bipolar disorder. The work is not just about which genes and genetic variations contribute to causing bipolar disorder, but also examines subtypes of bipolar disorder and patterns of medication response. Partly due to genetic differences, people experience different benefits and side effects to the same medications.

Researchers at Mayo are exploring the various factors, genetic in particular, that may be associated with people’s responses to antidepressants for bipolar depressive episodes: Why some people benefit, others show no change, and some have negative outcomes. Eventually this will be extremely valuable information for doctors to have – at least to know whether people with certain genetic profiles should avoid specific medications.

The Mayo bipolar biobank and research network will also be collecting brain scans from some people as they research the antidepressant issue and other questions about bipolar disorder, and this information could be tied into the data from the biobank.

Biobanking is becoming much more common – institutions all over the world, with a variety of disease and population interests, are getting involved. It’s thought to be one of the best ways to collect the huge amounts of genetic information needed to really get useful information from genetic studies.

As this is new technology and the practices associated with it grow, they’re sure to generate many questions and discussions about ethics and privacy, but hopefully they will also produce prescription guidelines that enable doctors to prescribe medications that are more effective and less likely to result in negative side effects based on each individual’s genetic profile.

Photo by Image Editor, available under a Creative Commons attribution license.

 


Comments


View Comments / Leave a Comment

This post currently has 1 comments.
You can read the comments or leave your own thoughts.

Trackbacks

From Psych Central's World of Psychology:
Best of Our Blogs: April 29, 2011 | World of Psychology (April 29, 2011)






    Last reviewed: 28 Apr 2011

APA Reference
Fink, C. (2011). Using Genetic Profiles to Predict Medication Response in Bipolar Disorder. Psych Central. Retrieved on December 23, 2014, from http://blogs.psychcentral.com/bipolar/2011/04/genetic-profile-predict-medication-response-bipolar-disorder/

 

Bipolar Beat


Subscribe to this Blog:
Feed

Bipolar
Disorder



Archives





Candida Fink, M.D. and Joe Kraynak are authors of
Bipolar Disorder for Dummies.


Best of the Web - Blog 2008

Subscribe to this Blog: Feed

Recent Comments
  • Bubblewrapopper: I gained 60 lbs in a year on Depakote and Depo-Provera, the birth control shot when I had just...
  • Lisa Keith, Psy.D.: I agree John, abilify is a mood stabilizer for dysregulation disorders and not indicated for...
  • Lisa Keith, Psy.D.: Thank you for posting this information. I have been on abilify and cymbalta together for going on...
  • bishinri: So sorry for your heartbreak and pain. The trauma is indescribable. Hope you are moving on and in a healthy...
  • bishinri: Yes…self sabotage is a great description for it. It is like a self defense mechanism or something....
Find a Therapist
Enter ZIP or postal code



Users Online: 12240
Join Us Now!