With this post, we continue our biweekly series on medications used to treat bipolar disorder and related symptoms. We have already covered lithium, along with anti-seizure and atypical antipsychotics commonly used as anti-manic medications or mood stabilizers in bipolar disorder. We introduced our coverage of SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants with a post on Prozac (fluoxetine). This week, we continue our series on SSRI antidepressants with this post on Luvox (fluvoxamine).

As a group, the SSRI’s share many of the same potential benefits and potential negative side effects, so we encourage you to read the Prozac post first to get up to speed about general information relating to SSRI’s, including how SSRI’s work and important cautions about using any antidepressant to treat depression in bipolar. In this post, we focus on Luvox’s profile in treating bipolar depression and depression in general.

Potential Benefits

The name brand Luvox is not longer available – it is only available as a generic, fluvoxamine. Luvox CR is newer version, which is a once-a-day product as opposed to the twice-a-day dosing required with generic fluvoxamine.

Luvox has FDA indications for the treatment of Social Anxiety Disorder and OCD (its most common usage). It is approved for the treatment of OCD for children as young as 8 years old.

Luvox may also be useful in treating other anxiety and mood disorders, including the following:

• Unipolar depression
• Bipolar depression
• Post Traumatic Stress Disorder (PTSD)
• Bulimia nervosa
• Generalized Anxiety Disorder (GAD)
• Panic Disorder

Typical Dose

Typical adult doses of Luvox range from 50 mg to 300 mg taken once daily, higher in some cases, same time each day, but follow your prescriber’s recommendations on dose and when to take it.

Potential Side Effects

Like most medications in its class, Luvox can potentially cause any of several negative side effects. The most serious are the following:

• Increased suicidal thoughts in children or teens: Clearly there is an increased risk of suicide and suicidal thinking in people with bipolar and depression as a whole. A large review of studies done on children and adolescents who were treated with antidepressants showed that there was a slight increase in the risk that these children would develop suicidal thoughts, compared to children taking placebo. Even with the increased risk, the rate of this side effect remains very, very low. And the increased risk relates only to suicidal thinking- there have been no reports indicating any increased risk of completed suicides with the medications. These medications are far more likely to decrease the risk of suicide than to increase it. Careful monitoring and communication with the prescriber, especially early on in treatment with SSRI’s, is essential in reducing this risk as much as possible.
• Increased risk of mania: As mentioned earlier in this post, a person with bipolar disorder taking an antidepressant without the protection of a mood stabilizer may be at higher risk of shifting into mania or hypomania. While there is some indication that some antidepressants have less risk of manic switching, the risk seems to be present in all antidepressants. The rate of switching and the actual level of risk is not clear at this time – some researchers suspect it is very high and others feel it is actually much lower than is generally presumed.
• Agitation, increased anxiety, or worsening depression or other paradoxical effects: This is not the same as a true manic switch, and can occur in people with or without bipolar disorder who take SSRI’s. In a small group of people, these medicines seem to irritate the brain wiring rather than soothe it. This appears to be more common in children and adolescents, but can occur in a subset of adults as well. Close monitoring with your prescriber will be important in detecting this.
• Serotonin syndrome: When combined with medicines used to treat migraine headaches known triptans, such as sumatriptan (Imitrex), or other drugs that elevate brain levels of serotonin (including the illegal drug Ecstasy), a life-threatening condition called serotonin syndrome can occur. Symptoms include restlessness, hallucinations, loss of coordination, racing heart, increased body temperature, blood pressure fluctuations, overactive reflexes, diarrhea, nausea, vomiting, coma, and possibly death.
• Persistent pulmonary hypertension of the newborn (PPHN): There are studies showing that babies born to mothers who were taking SSRI’S in the third trimester of pregnancy have an increased likelihood of this condition. Babies born with PPHN have restricted blood flow through their heart and lungs, reducing the supply of oxygen to their bodies. This can make them very ill and increase their risk of death. If you’re pregnant or planning to become pregnant, consult with the doctor who’s managing your medications.

Luvox has a number of interactions with other medications, so it is important to review your entire medication regimen with your physician before starting Luvox or adding another medication while already taking Luvox. There are interactions with the benzodiazepines (tranquilizers), as well as certain sleep medicines and a number of medicines for other health issues.

Other less serious side effects can include the following (Note: Many of these side effects are transient and occur when first taking these medications but do not persist.):

• Sweating
• Sleepiness
• Insomnia
• Nausea
• Diarrhea
• Tremor
• Dry mouth
• Loss of strength
• Headache
• Weight loss or gain
• Dizziness
• Restlessness
• Mania
• Changes in sexual function

Remember: Any antidepressant can take 2-3 weeks or even longer to become fully effective; it may take several weeks to work up to a therapeutic dose. This means that your depression may not lift for several weeks. I often tell patients however they feel in the first two weeks is unlikely to be how they feel in a month – so if they are feeling some early side effects, hold on because they will likely get better. Patience is important in getting these medications to work, but if you have any concerns about how you are feeling, you should contact your doctor. You will most likely have a follow-up visit with your doctor within a month or less of starting the medications; this is a good time frame for checking in to see if benefits have started or if side effects have faded or persisted.

Since Luvox has a childhood indication, I use it frequently in my young patients for OCD and for anxiety disorders. It is less commonly used for depression and bipolar depression – particularly the latter due to the risk of triggering mania or agitation. However, if there is depression along with OCD or other severe anxiety symptoms Luvox can be a powerful tool in the tool box.

The most common potential side effect is sleepiness, so we titrate the dose up fairly slowly, which means it can take longer to work. Also, the interactions with other drugs can make it a more difficult medication to prescribe, particularly in adults with any medical conditions.

For more about Luvox CR (extended-release capsules), visit Solvay Pharmaceuticals’ LuvoxCR page.

If you’ve taken any form of Luvox for bipolar depression or other conditions or are a doctor who has prescribed it, please share your experiences, insights, and observations.

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